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KOMP 2 Phenotyping Effort

Ube2e2

Name:ubiquitin-conjugating enzyme E2E 2
Resources: MGI:2384997 NCBI:218793 OMIM, PubMed, Gene Cloud, Additional resources at KOMP
Products:vector, ESC, sperm, embryo
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SHIRPA Observations in Viewing Jar

Body Position

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Active
Inactive
Excessive Activity

Coat Appearance

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Tidy - well groomed
Irregularities (piloerect, etc)

Defecation

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Present
Absent

Head Bobbing

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Absent
Present

Head Flicking

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Absent
Present

Lacrimation

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Absent
Present

Palpebral Closure

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Eyes open
Eyes closed

Tremor

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Absent
Present

Whiskers

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Present
Absent

FOB Arousal

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Normal (alert, exploratory bhvr)
Very high (hyperalert, excited, sudden mvmts)
Somewhat High (slight excitement, tense, darting)
Low (some hd and body mvmt)
Somewhat low (some exploration with immobility )
Very low (coma, stupor)

SHIRPA Behavior Recorded in Arena

Gait

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Fluid ~ 3mm pelvic elevation
Lack of fluidity

Startle Response (from FOB)

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Freezes or whole body startle
No reaction
Exaggerated (jumps, bites, attacks)
Slight reactions (evidence noise was heard)
Moderate reaction

Tail Elevation

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Horizontal extension
Dragging
Elevated/straub tail

Touch Escape

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Flees prior to touch
Response to touch
No response

Transfer Arousal

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Brief freeze (2-5 sec) then movement
Extended Freeze (over 5 sec)
Immediate movement (< 1 sec freeze)

FOB Clonic Movements

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Normal
Myoclonic jerks
Repetitive mvmts of mouth and jaws
Severe or whole body tremors
Clonic convulsions
Quivers of limbs, ears, head or skin
Mild tremors
wet dog shakes

FOB Gait

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Normal
Hind limbs (drag, or splayed)
Forelimbs drag, extended, not supporting
Hunched or crouched body position
Ataxia (Excessive sway, rocks or lurches)
Feet markedly point outward
Walks on tiptoes
Body drags or flattened on surface

FOB Tonic Movements

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Normal
Opisthotonos (hd & body rigidly arched back)
Explosive jumps
Contractions of extensors (limbs rigid)
Emprosthotonos (hd & body rigidly extended fwd
Severe clonic &/or tonic convulsions

SHIRPA Observations above Arena

Positional Passivity

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Tail - Struggles
Neck - Struggles
No struggle
Supine - Struggles

Skin Color

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Pink
Blanched
Bright deep red flush

Tail Suspension (20 sec)

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Normal splay of limbs
Turns up sides
Grabs contralateral leg
Forepaw clutch
Grabs ipsilateral leg
Hindpaw clutch
Other responses

Trunk Curl

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Absent
Present

SHIRPA Reflexes

Corneal Reflex (tail restrain)

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Present
Absent

Pinna Reflex (do not restrain)

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Present
Absent

Other SHIRPA Tests

Biting

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

None
Biting

Contact Righting Reflex

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Present
Absent

Vocalization

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

None
Vocalization

Geotaxis and Strength

Hanging Wire Grid Test (60 sec)

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

> 1 min
Invalid
0 to 30s
Falls immediately
30s to 1 min

Vertical Screen Test (20 sec)

het malehet fem
HET
hom malehom fem
HOM
wt malewt fem
WT Littermate
malefemale
WT Pop
0%
20%
40%
60%
80%
100%

Climbs to the top of the screen in 20 sec
Turns upward, does not climb to top
Falls; or remains on the bottom of the screen upside down
Climbs past middle in 20 sec

The KOMP Phenotyping Project is funded by an ARRA grant to UC Davis and CHORI.

Questions? Comments? Please contact us: 1-888-KOMP-MICE or service@komp.org