Description: The FOB is a series of situations applied to the animal to determine gross sensory and motor deficits. A subset of tests from the Irwin neurological screen that evaluates gross neurological function is used. In general, short-duration, tactile, olfactory, and visual stimuli are applied to the animal to determine their ability to detect and respond normally. These simple tests take approximately 10 minutes and the mouse is returned to its home cage at the end of testing. Temperature Assay: Mouse body temperature was determined by gently inserting a small probe into the rectum and recording the temperature with a digital read-out. This process takes less than 5 seconds.

Measurements: Abnormal Gait, Bald Hair Patches, Body Posture Adjustment Fall Over, Body Posture Adjustment Normal Splay Limbs, Catalepsy Response, Circling, Curly Kinked Tail, Defecation, Exophthalmus, Freezing, Head Bobbing, Head Flicking, Jumping, Kyphosis, Licking, Lordosis, Move All Around Cage, Olfactory Response, Palpebral Closure, Piloerection, Prancing Forelimbs, Pupil Reflex, Rearing, Retropulsion, Righting Reflex, Sniffing, Straub Tail, Tail Suspension Forepaw Clutch, Tail Suspension Grab Contralateral Leg, Tail Suspension Grab ipsilateral Leg, Tail Suspension Hindpaw Clutch, Tail Suspension Normal Splay Limbs, Tail Suspension Other Responses, Tail Suspension Turn Up Sides, Temperature, Temperature Value, Touch Reflex ear, Touch Reflex eye, Touch Reflex flank, Urination, Visual Reaching, Waltzing, Whisker Orienting Response Turn Toward Touch, Whisker Orienting Response Whiskers Stop Moving, Whiskers, Wild Running