Description: Genetically-altered mutant mice created using transgenic and gene-targeting approaches may develop significant behavioral abnormalities solely as a result of their induced mutation. The KOMP Phenotyping Pilot project will test, examine, and compare 100 strains of homozygous knockouts and their wildtype littermates. Our primary behavioral tests are designed for "high-throughput" screenings of adult mutants to quickly and efficiently detect activity, memory, motivation, learning, cognitive, and motor ability (strength and coordination). Using the modified SHIRPA exam(SmithKline Beecham Pharmaceuticals; Harwell, MRC Mouse Genome Centre and Mammalian Genetics Unit; Imperial College School of Medicine at St Mary's; Royal London Hospital, St Bartholomew's and the Royal London School of Medicine; Phenotype Assessment), allows for quick yet thorough analysis of gross behavioral abnormalities. Following the SHIRPA exam is a detailed physical exam that allows the examiner to detect obvious and subtle morphological abnormalities. These methodologies adhere to analogous guidelines put in place by the European Phenotyping Consortium.